Tangential flow filtration (TFF)

Cell (or biomass) harvesting, or clarification of supernatant, are important processes in nearly all downstream purifications of biotech-based products.
When the product is internal to the cells, cell harvesting is used to decrease the liquid volume of cells to be processed in the product extraction steps.
Available methods for cell harvesting include TFF (Tangential Flow Filtration) and the combination of Centrifugation with depth filtration.

Unlike a dead-end impact filter where the product flows perpendicular to the filter (prone to clogging), the product stream in TFF moves in parallel to the filter. This allows solids to be kept in solution and minimizes the buildup of a "filter cake" which can foul the membrane.

Advantages of Tangential Flow Filtration
Meet your unique processing requirements with flexible filter solutions such as batch and fed batch ultrafiltration.
Today's industrial design -- even in compact, benchtop TFF systems -- provides for accurate and continuous transitions to scaling up.                           

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