If not directly administered back to patient, a cryopreservation is needed for storage.
Cells are then transported back to the clinical center under controlled temperature conditions.
Cryopreservation technology has developed into a fundamental and important supporting method for biomedical applications such as cell‐based therapeutics, tissue engineering, assisted reproduction, and vaccine storage.
How Does Cryopreservation Impact the Viability of Cellular Therapies?
The formation, growth, and recrystallization of ice crystals are the major limitations in cell/tissue/organ cryopreservation, and cause fatal cryoinjury to cryopreserved biological samples.
In the unique supply chain of cellular therapies, preservation is important to keep the cell product viable. Many factors in cryopreservation affect the outcome of a cell therapy:
-
Formulation and introduction of a freezing medium
-
Cooling rate
-
Storage conditions
-
Thawing conditions
-
Post-thaw processing
Your challenges
Do your cryopreservation process impact T cell recovery, viability, or functionality?
Are you cGMP or GLP compliant? Is your alarm monitoring system reliable? Can you map temperature homogeneity?
Our Solutions for your Workflow
Sources :
Meneghel, J., Kilbride, P., & Morris, G. J. (2020). Cryopreservation as a Key Element in the Successful Delivery of Cell-Based Therapies-A Review. Frontiers in medicine, 7, 592242.
https://doi.org/10.3389/fmed.2020.592242
Li, R., Johnson, R., Yu, G., McKenna, D. H., & Hubel, A. (2019). Preservation of cell-based immunotherapies for clinical trials. Cytotherapy, 21(9), 943–957.
https://doi.org/10.1016/j.jcyt.2019.07.004