Blood grouping reagents for the detection of the Fya antigen on human red cells
Sanquin monoclonal blood grouping reagents (clone numbers are mentioned on the corresponding certificate of analysis/release document and product label) are prepared from culture supernatants from stable hybridoma cell lines as first described by Köhler and Milstein (Nature 1975). This monoclonal reagent contains human IgG antibodies and has been specially selected and developed to provide a reliable alternative to polyclonal reagents. This reagent meets the requirements of the concerned standards and guidelines. Performance characteristics are mentioned in the release documents, which are supplied with the product upon request. The principle of the test is the agglutination technique, which is based on antigen/antibody reaction. The inclusion of positive and negative controls with each series of blood group determinations is strongly recommended.